Integrative Genomics and Systems Biology of Common Metabolic Disorders and Comorbidity
Research in our lab employs integrative multiomics and systems biology approaches to understand the molecular networks underlying common cardiometabolic disorders including coronary artery disease, diabetes, obesity, and non-alcoholic fatty liver disease. We are also investigating the molecular mechanisms that connect cardiometabolic disorders with brain disorders.
Common cardiometabolic disorders represent top health concerns worldwide. Decades of research only reveals greater complexity in the genetic architecture of individual diseases, the connections among them, and the links between cardiometabolic disorders and other diseases. We hypothesize that the complex interactions between genetic and environmental risk factors perturb specific gene networks which in turn induce variations in disease susceptibility and therapeutic response. Click here if you want to learn more about our research.
By developling and applying integrative multiomics and systems biology approaches that leverage genetic, transcriptional, epigenomic, metabolomic, microbiome, and phenotypic data from human and rodent populations, we aim to identify causal molecular alterations and the subsequently perturbed molecular networks that contribute to the development of cardiometabolic diseases and their comorbidity.
Our lab have developed Mergeomics and Pharmomics tools for muti-omics data integration and drug repurposing, respectively. For more details, please click here.
Our research is generously supported by the NIH NIDDK, NINDS, and the NHLBI.
A disease network and key regulators. Figure credit: Jenny Cheng
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