Rio & Zeyneb
Undergraduate Summer Program 2016
Xia, Ugoma, & Ashok

Latest News

  1. Congratulations to Dr. Yanning Zuo for passing her Ph.D defense!
  2. Congratulations to Jessica Ding for receiving the NIAMS UCLA T32 Dermatology Scientist Training Fellowship Program
  3. Congratulations to Gaoyan Li for receiving the Iris Cantor-UCLA Women’s Health Center-CTSI Young Investigator Award!
  4. Congratulations to Monty Blencowe for receiving the IBP Hyde Fellowship!
  5. Congratulations to Zac Zamora for receiving the Cota-Robles Fellowship!
  6. Congratulations to Thomas Kowal-Safron for receiving the Mol Tox T32 Predoctoral Fellowship!
  7. Congratulations to Monty Blencowe for the preview in Cell Reports Medicine on a new Cell Systems paper focusing on conserved networks of liver diseases across species.
  8. Congratulations to Yanning Zuo, Carissa Zhu, Ormina Naveed and colalborators Drs. Don Wei and Weizhe Hong for publishing our review paper on network modeling of psychiatric disorders in Genes.
  9. Congratulations to Monty Blencowe on a collaborative paper accepted by Diabetologia on transcriptome analysis of mouse models with toxic vs non-toxic App in islets.
  10. The JSTA method led by Russell Littman  with contributions from Dr. Douglas Arneson and Dr. Guanglin Zhang, is published in Molecular Systems Biology. A great collaboration with the Wollman lab. Congratulations to the team!

Integrative Genomics and Systems Biology of Common Metabolic Disorders and Comorbidity

Research in our lab employs integrative multiomics and systems biology approaches to understand the molecular networks underlying common cardiometabolic disorders including coronary artery disease, diabetes, obesity, and non-alcoholic fatty liver disease. We are also investigating the molecular mechanisms that connect cardiometabolic disorders with brain disorders.

Common cardiometabolic disorders represent top health concerns worldwide. Decades of research only reveals greater complexity in the genetic architecture of individual diseases, the connections among them, and the links between cardiometabolic disorders and other diseases. We hypothesize that the complex interactions between genetic and environmental risk factors perturb specific gene networks which in turn induce variations in disease susceptibility and therapeutic response. Click here if you want to learn more about our research.

By developling and applying integrative multiomics and systems biology approaches that leverage genetic, transcriptional, epigenomic, metabolomic, microbiome, and phenotypic data from human and rodent populations, we aim to identify causal molecular alterations and the subsequently perturbed molecular networks that contribute to the development of cardiometabolic diseases and their comorbidity.

Our lab have developed Mergeomics and Pharmomics tools for muti-omics data integration and drug repurposing, respectively. For more details, please click here.

Our research is generously supported by the NIH NIDDK, NINDS, and the NHLBI.

A disease network and key regulators. Figure credit: Jenny Cheng

National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Neurological Disorders and Stroke National Heart, Lung, and Blood Institute
American heart association JDRF JDRF