Research in our lab employs integrative genomics and systems biology approaches to understand the molecular mechanisms underlying common metabolic disorders including coronary artery disease, diabetes, and obesity. We are also investigating the molecular mechanisms that connect metabolic disorders with brain function and neurological disorders.
Common metabolic disorders represent top health concerns worldwide. Decades of research only reveals greater complexity in the genetic architecture of individual diseases, the connections between them, and the links between metabolic disorders and other diseases. We hypothesize that the complex interactions between genetic and environmental risk factors perturb specific gene networks which in turn induce variations in disease susceptibility and therapeutic response. Click here if you want to learn more about our research.
By applying integrative genomics and systems biology approaches that leverage genetic, transcriptional, epigenomic, and phenotypic data from human and rodent populations, we attempt to identify causal molecular alterations and the subsequently perturbed molecular networks that contribute to the development of obesity, diabetes, cardiovascular diseases, and their comorbidity. In this regard, we have developed Mergeomics and Pharmomics for muti-omics data analysis and drug toxicity & repurposing, respectively. For more details, please click here.
Our research is generously supported by the NIH NIDDK, NINDS, and the NHLBI.
A disease network and key regulators. Figure credit: Jenny Cheng