Rio & Zeyneb
Undergraduate Summer Program 2016
Xia, Ugoma, & Ashok

Latest News!

  1. Congratulations to Zac Zamora and Zoe Zhao for being admitted to UCLA Ph.D. programs.
  2. Our lab was awarded a grant from JDRF to understand gene networks underlying T1D metabolic complications and to identify drug repositioning candidates. We appreciate the general support from JDRF and special thanks to Monty Blencowe for his hard work on this project!
  3. Our study on the network modeling of plasma lipid traits accepted by Journal of Lipid Research. Congratulations to Monty Blencowe, Dr. In Sook Ahn, Zara Saleem, and Ingrid Cely
  4. Congratulations to Dr. Daniel Ha for receiving the QCBio Collaboratory Fellowship!
  5. Our systems toxicogenomics study of maternal low dose BPA exposure on the liver-gut axix and metabolic health in offspring was accepted by Environment International! Congratulations to Dr. Graciel Diamante, Ingrid Cely, Zac Zamora, Jessica Ding, Montgomery Blencowe, and our collaborators in the Jake Lusis lab
  6. Dr. Guanglin Zhang, Dr. Qingying Meng, Montgomery Blencowe’s systems nutrigenomics study was accepted by Molecular Nutrition and Food Research

Integrative Genomics and Systems Biology of Common Metabolic Disorders and Comorbidity

Research in our lab employs integrative genomics and systems biology approaches to understand the molecular mechanisms underlying common metabolic disorders including coronary artery disease, diabetes, and obesity. We are also investigating the molecular mechanisms that connect metabolic disorders with brain function and neurological disorders.

Common metabolic disorders represent top health concerns worldwide. Decades of research only reveals greater complexity in the genetic architecture of individual diseases, the connections between them, and the links between metabolic disorders and other diseases. We hypothesize that the complex interactions between genetic and environmental risk factors perturb specific gene networks which in turn induce variations in disease susceptibility and therapeutic response. Click here if you want to learn more about our research.

By applying integrative genomics and systems biology approaches that leverage genetic, transcriptional, epigenomic, and phenotypic data from human and rodent populations, we attempt to identify causal molecular alterations and the subsequently perturbed molecular networks that contribute to the development of obesity, diabetes, cardiovascular diseases, and their comorbidity. In this regard, we have developed Mergeomics and Pharmomics for muti-omics data analysis and drug toxicity & repurposing, respectively. For more details, please click here.

Our research is generously supported by the NIH NIDDK, NINDS, and the NHLBI.

A disease network and key regulators. Figure credit: Jenny Cheng

National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Neurological Disorders and Stroke National Heart, Lung, and Blood Institute