Rio & Zeyneb
Undergraduate Summer Program 2016
Xia, Ugoma, & Ashok

Latest News!

  1. The JSTA method led by Russell Littman  with contributions from Dr. Douglas Arneson and Dr. Guanglin Zhang, has now been accepted by Molecular Systems Biology. A great collaboration with the Wollman lab. Congratulations to the team!
  2. Our Mergeomics V2.0 is accepted by Nucleic Acids Research! Congratulations to Jessica Ding, Monty Blencowe, Thien Nghiem, Daniel Ha, Yen-Wei Chen, and Gao Yan Li
  3. Our collaborative paper on the conservation and differences in astrocyte functions between mouse and human, led by Dr. Ye Zhang’s group is accepted by Nature Communications. Congratulations to Yen-Wei Chen
  4. Congratulations to Graciel Diamante  for receiving the Chancellor’s Award for Postdoctoral Research
  5. Congratulations to Russell Littman for receiving the iDiscovery Cardiovascular Data Science predoctoral fellowship!
  6. Congratulations to Wendy Su for receiving the prestigious UC LEADS Fellowship award
  7. Congratulations to Monty Blencowe for receiving the prestigous American Heart Association Predoctoral Fellowship award
  8. Congratulations to Zac Zamora and Zoe Zhao for being admitted to UCLA Ph.D. programs
  9. Our lab was awarded a grant from JDRF to understand gene networks underlying T1D metabolic complications and to identify drug repositioning candidates. We appreciate the general support from JDRF and special thanks to Monty Blencowe for his hard work on this project!
  10. Our study on the network modeling of plasma lipid traits accepted by Journal of Lipid Research. Congratulations to Monty Blencowe, Dr. In Sook Ahn, Zara Saleem, and Ingrid Cely

Integrative Genomics and Systems Biology of Common Metabolic Disorders and Comorbidity

Research in our lab employs integrative genomics and systems biology approaches to understand the molecular mechanisms underlying common metabolic disorders including coronary artery disease, diabetes, and obesity. We are also investigating the molecular mechanisms that connect metabolic disorders with brain function and neurological disorders.

Common metabolic disorders represent top health concerns worldwide. Decades of research only reveals greater complexity in the genetic architecture of individual diseases, the connections between them, and the links between metabolic disorders and other diseases. We hypothesize that the complex interactions between genetic and environmental risk factors perturb specific gene networks which in turn induce variations in disease susceptibility and therapeutic response. Click here if you want to learn more about our research.

By applying integrative genomics and systems biology approaches that leverage genetic, transcriptional, epigenomic, and phenotypic data from human and rodent populations, we attempt to identify causal molecular alterations and the subsequently perturbed molecular networks that contribute to the development of obesity, diabetes, cardiovascular diseases, and their comorbidity. In this regard, we have developed Mergeomics and Pharmomics for muti-omics data analysis and drug toxicity & repurposing, respectively. For more details, please click here.

Our research is generously supported by the NIH NIDDK, NINDS, and the NHLBI.

A disease network and key regulators. Figure credit: Jenny Cheng

National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Neurological Disorders and Stroke National Heart, Lung, and Blood Institute