Our multitissue single cell study of metabolic syndrome induced by high fructose or high fat high sucrose diets, co-led by Drs. Yen-Wei Chen and In Sook Ahn, is published in Cell Reports. This study revealed distinct cell type and molecular vulnerability and tissue crosstalk between hypothalamus, liver, adipose tissue, and small intestine between diets, and identified a central metabolic regulator, mt-Rnr2, in counteracting diet-induced metabolic syndrone.
